Increased basal ganglia iron levels in Huntington disease

George Bartzokis, Jeffrey Cummings, Susan Perlman, Darwood B. Hance, Jim Mintz

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Objective: To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects. Design and Subjects: A magnetic resonance imaging method that can quantify ferritin iron levels with specificity in vivo was employed to study 11 patients with HD and a matched group of 27 normal controls. Three basal ganglia structures (caudate, putamen, and globus pallidus) and 1 comparison region (frontal lobe white matter) were evaluated. Results: Basal ganglia iron levels were significantly increased (P<.002) in patients with HD, and this increase occurred early in the disease process. This was not a generalized phenomenon, as white matter iron levels were lower in patients with HD. Conclusions: The data suggest that increased iron levels may be related to the pattern of neurotoxicity observed in HD. Reducing the oxidative stress associated with increased iron levels may offer novel ways to delay the rate of progression and possibly defer the onset of HD.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalArchives of Neurology
Volume56
Issue number5
DOIs
StatePublished - May 1999

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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