Increased amygdala activation during mania: A functional magnetic resonance imaging study

Lori Altshuler, Susan Bookheimer, Manuel A. Proenza, Jennifer Townsend, Fred Sabb, Ann Firestine, George Bartzokis, Jim Mintz, John Mazziotta, Mark S. Cohen

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


Objective: This study sought to investigate neural activity in the amygdala during episodes of mania. Method: Nine manic subjects and nine healthy comparison subjects underwent functional magnetic resonance imaging (fMRI) while performing a neuropsychological paradigm known to activate the amygdala. Subjects viewed faces displaying affect (experimental task) and geometric forms (control task) and matched them to one of two simultaneously presented similar images. Results: Manic subjects had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbitofrontal cortex relative to the comparison subjects. Conclusions: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.

Original languageEnglish (US)
Pages (from-to)1211-1213
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number6
StatePublished - Jun 2005
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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