Incorporating severity of illness into estimates of likelihood ratios

M. Lichtenstein, C. Kiefe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Although severity of illness may affect the usefulness of a diagnostic test, most previous work has considered test performance only in the dichotomous situation where the target disorder is considered present or absent. In this paper, a clinical example is provided and two methods presented whereby illness severity may be incorporated into the determination of likelihood ratios for a diagnostic test. The use of this approach is that given a test result, a clinician may determine the post-test probability of all levels of the illness in the patient under study.

Original languageEnglish (US)
Pages (from-to)38-42
Number of pages5
JournalAmerican Journal of the Medical Sciences
Issue number1
StatePublished - 1990


  • diagnostic test
  • likelihood ratios
  • sensitivity
  • specificity

ASJC Scopus subject areas

  • Medicine(all)


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