Incidence of Hepatocellular Carcinoma in Texas Latinos, 1995-2010: An update

Amelie G Ramirez, Edgar Munoz, Alan E C Holden, Rebecca T. Adeigbe, Lucina Suarez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: A previous study showed Hepatocellular Carcinoma (HCC) rates to be higher among Latinos in Texas and highest among South Texas Latinos compared to other non-Hispanic whites (NHW) and other Latinos in the United States (U.S.). We used more recent data to assess trends in HCC among Texas Latinos and to reassess the elevated HCC incidence rate in Texas Latinos. Methods: We used data from the U.S. SEER Program and the Texas Cancer Registry to calculate annual and 3-year moving average age-specific and age-adjusted HCC incidence rates, annual percent changes (APCs), and their corresponding 95% confidence intervals for Latinos and NHW in the U.S., Texas and South Texas. Results: Texas Latino male and female incidence rates were 3.1 and 4.0 times higher than their NHW counterparts in SEER regions. Latino males and females in South Texas had the highest rates of HCC incidence overall; rate ratios were 3.6 and 4.2 among South Texas Latino males and females compared to SEER NHW counterparts. There are statistically significant increases in HCC incidence rates in all groups (Texas and South Texas Latinos and NHW groups) and across all age groups. The elevated HCC rates in Texas Latinos are consistent over the 1995-2010 period. Conclusions: The incidence of HCC among Latinos in South Texas remains higher than elsewhere in the U.S. and warrants closer investigation of potential risk factors related to prevailing conditions unique to the population including higher obesity and diabetes rates, environmental, cultural and socioeconomic factors and possibly genetic predisposition.

Original languageEnglish (US)
Article numbere99365
JournalPLoS One
Volume9
Issue number6
DOIs
StatePublished - Jun 10 2014

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hepatoma
Medical problems
Hispanic Americans
Hepatocellular Carcinoma
incidence
Incidence
SEER Program
governmental programs and projects
socioeconomic factors
Genetic Predisposition to Disease
diabetes
Registries
confidence interval
obesity
risk factors
Age Groups
Obesity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Incidence of Hepatocellular Carcinoma in Texas Latinos, 1995-2010 : An update. / Ramirez, Amelie G; Munoz, Edgar; Holden, Alan E C; Adeigbe, Rebecca T.; Suarez, Lucina.

In: PLoS One, Vol. 9, No. 6, e99365, 10.06.2014.

Research output: Contribution to journalArticle

Ramirez, Amelie G ; Munoz, Edgar ; Holden, Alan E C ; Adeigbe, Rebecca T. ; Suarez, Lucina. / Incidence of Hepatocellular Carcinoma in Texas Latinos, 1995-2010 : An update. In: PLoS One. 2014 ; Vol. 9, No. 6.
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abstract = "Background: A previous study showed Hepatocellular Carcinoma (HCC) rates to be higher among Latinos in Texas and highest among South Texas Latinos compared to other non-Hispanic whites (NHW) and other Latinos in the United States (U.S.). We used more recent data to assess trends in HCC among Texas Latinos and to reassess the elevated HCC incidence rate in Texas Latinos. Methods: We used data from the U.S. SEER Program and the Texas Cancer Registry to calculate annual and 3-year moving average age-specific and age-adjusted HCC incidence rates, annual percent changes (APCs), and their corresponding 95{\%} confidence intervals for Latinos and NHW in the U.S., Texas and South Texas. Results: Texas Latino male and female incidence rates were 3.1 and 4.0 times higher than their NHW counterparts in SEER regions. Latino males and females in South Texas had the highest rates of HCC incidence overall; rate ratios were 3.6 and 4.2 among South Texas Latino males and females compared to SEER NHW counterparts. There are statistically significant increases in HCC incidence rates in all groups (Texas and South Texas Latinos and NHW groups) and across all age groups. The elevated HCC rates in Texas Latinos are consistent over the 1995-2010 period. Conclusions: The incidence of HCC among Latinos in South Texas remains higher than elsewhere in the U.S. and warrants closer investigation of potential risk factors related to prevailing conditions unique to the population including higher obesity and diabetes rates, environmental, cultural and socioeconomic factors and possibly genetic predisposition.",
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