Abstract
Background: MARK4 is a member of the AMPK-related kinase family whose biological function remains elusive. Results: Using mice with targeted deletion of mark4, we identified a key role of the kinase in regulating glucose and energy homeostasis. Conclusion: MARK4 is required for energy homeostasis by regulating satiety and the metabolic rate in rodents. Significance: These data provide a key insight for targeting MARK4 for the treatment of obesity.
Original language | English (US) |
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Pages (from-to) | 38305-38315 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 45 |
DOIs | |
State | Published - Nov 2 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology