Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin Hypersensitivity and resistance to diet-induced obesity

Chao Sun, Liang Tian, Jia Nie, Hai Zhang, Xiao Han, Yuguang Shi

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Background: MARK4 is a member of the AMPK-related kinase family whose biological function remains elusive. Results: Using mice with targeted deletion of mark4, we identified a key role of the kinase in regulating glucose and energy homeostasis. Conclusion: MARK4 is required for energy homeostasis by regulating satiety and the metabolic rate in rodents. Significance: These data provide a key insight for targeting MARK4 for the treatment of obesity.

Original languageEnglish (US)
Pages (from-to)38305-38315
Number of pages11
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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