In vivo stimulation of rat pineal type II thyroxine 5'-deiodinase activity by either norepinephrine or isoproterenol

J. M. Guerrero, C. Santana, Russel J Reiter

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Abstract

Herein we show, for the first time, a very marked increase in thyroxine 5'-deiodinase (5'-D) activity in rats injected with norepinephrine (NE) and desmethylimipramine, a drug which inhibits NE uptake by nerve terminals. The response to NE was greater in pineals collected from hypothyroid animals than in glands from euthyroid animals. NE was more effective in stimulating pineal 5'-D than was isoproterenol, suggesting that, in addition to β-adrenergic receptors, α-adrenergic receptors might be involved in the 5'-D activation. However, phenylephrine, an α-adrenergic agonist, did not potentiate the effect of isoproterenol on pineal 5'-D activity. The nocturnal increase in pineal 5'-D activity was completely abolished by propranolol, a β-adrenergic receptor blocker, while prazosin, an α-adrenergic receptor blocker, had minimal effect. These results show that the role of α-receptors in promoting the NE-mediated rise in rat pineal 5'-D activity is minor in contrast to the role of β-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume194
Issue number4
StatePublished - 1990

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Iodide Peroxidase
Isoproterenol
Adrenergic Receptors
Rats
Norepinephrine
Adrenergic Antagonists
Animals
Adrenergic Agonists
Desipramine
Prazosin
Phenylephrine
Propranolol
Chemical activation
iodothyronine deiodinase type II
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "In vivo stimulation of rat pineal type II thyroxine 5'-deiodinase activity by either norepinephrine or isoproterenol",
abstract = "Herein we show, for the first time, a very marked increase in thyroxine 5'-deiodinase (5'-D) activity in rats injected with norepinephrine (NE) and desmethylimipramine, a drug which inhibits NE uptake by nerve terminals. The response to NE was greater in pineals collected from hypothyroid animals than in glands from euthyroid animals. NE was more effective in stimulating pineal 5'-D than was isoproterenol, suggesting that, in addition to β-adrenergic receptors, α-adrenergic receptors might be involved in the 5'-D activation. However, phenylephrine, an α-adrenergic agonist, did not potentiate the effect of isoproterenol on pineal 5'-D activity. The nocturnal increase in pineal 5'-D activity was completely abolished by propranolol, a β-adrenergic receptor blocker, while prazosin, an α-adrenergic receptor blocker, had minimal effect. These results show that the role of α-receptors in promoting the NE-mediated rise in rat pineal 5'-D activity is minor in contrast to the role of β-adrenergic receptors.",
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AU - Santana, C.

AU - Reiter, Russel J

PY - 1990

Y1 - 1990

N2 - Herein we show, for the first time, a very marked increase in thyroxine 5'-deiodinase (5'-D) activity in rats injected with norepinephrine (NE) and desmethylimipramine, a drug which inhibits NE uptake by nerve terminals. The response to NE was greater in pineals collected from hypothyroid animals than in glands from euthyroid animals. NE was more effective in stimulating pineal 5'-D than was isoproterenol, suggesting that, in addition to β-adrenergic receptors, α-adrenergic receptors might be involved in the 5'-D activation. However, phenylephrine, an α-adrenergic agonist, did not potentiate the effect of isoproterenol on pineal 5'-D activity. The nocturnal increase in pineal 5'-D activity was completely abolished by propranolol, a β-adrenergic receptor blocker, while prazosin, an α-adrenergic receptor blocker, had minimal effect. These results show that the role of α-receptors in promoting the NE-mediated rise in rat pineal 5'-D activity is minor in contrast to the role of β-adrenergic receptors.

AB - Herein we show, for the first time, a very marked increase in thyroxine 5'-deiodinase (5'-D) activity in rats injected with norepinephrine (NE) and desmethylimipramine, a drug which inhibits NE uptake by nerve terminals. The response to NE was greater in pineals collected from hypothyroid animals than in glands from euthyroid animals. NE was more effective in stimulating pineal 5'-D than was isoproterenol, suggesting that, in addition to β-adrenergic receptors, α-adrenergic receptors might be involved in the 5'-D activation. However, phenylephrine, an α-adrenergic agonist, did not potentiate the effect of isoproterenol on pineal 5'-D activity. The nocturnal increase in pineal 5'-D activity was completely abolished by propranolol, a β-adrenergic receptor blocker, while prazosin, an α-adrenergic receptor blocker, had minimal effect. These results show that the role of α-receptors in promoting the NE-mediated rise in rat pineal 5'-D activity is minor in contrast to the role of β-adrenergic receptors.

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