In vivo responses of the pineal gland of the Syrian hamster to isoproterenol or norepinephrine.

J. S. Lipton, L. J. Petterborg, S. Steinlechner, Russel J Reiter

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The influence of isoproterenol, a norepinephrine (NE) agonist, or NE itself on pineal melatonin levels in adult male Syrian hamsters was examined in a series of studies. Isoproterenol (3 mg/kg) failed to stimulate pineal melatonin production in hamsters kept under light:dark cycles of 14:10 or in hamsters that had been superior cervical ganglionectomized for 1 week. When the drug was given to animals kept under continual light for 7 days it caused a low-grade rise in pineal melatonin, however, this was not confirmed in a second experiment. When the dosage of isoproterenol was increased to 10 mg/kg and 2 injections of the drug were given (at 2 h intervals) pineal melatonin levels also did not exhibit a significant increase. Finally, the administration of NE at a dosage of either 2.5 or 5 mg/kg also failed to augment melatonin levels in the hamster pineal gland.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalProgress in Clinical and Biological Research
Volume92
StatePublished - 1982
Externally publishedYes

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Pineal Gland
Mesocricetus
Melatonin
Isoproterenol
Norepinephrine
Cricetinae
Photoperiod
Pharmaceutical Preparations
Light
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

In vivo responses of the pineal gland of the Syrian hamster to isoproterenol or norepinephrine. / Lipton, J. S.; Petterborg, L. J.; Steinlechner, S.; Reiter, Russel J.

In: Progress in Clinical and Biological Research, Vol. 92, 1982, p. 107-115.

Research output: Contribution to journalArticle

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