In vivo responses of the pineal gland of the Syrian hamster to isoproterenol or norepinephrine.

J. S. Lipton, L. J. Petterborg, S. Steinlechner, R. J. Reiter

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The influence of isoproterenol, a norepinephrine (NE) agonist, or NE itself on pineal melatonin levels in adult male Syrian hamsters was examined in a series of studies. Isoproterenol (3 mg/kg) failed to stimulate pineal melatonin production in hamsters kept under light:dark cycles of 14:10 or in hamsters that had been superior cervical ganglionectomized for 1 week. When the drug was given to animals kept under continual light for 7 days it caused a low-grade rise in pineal melatonin, however, this was not confirmed in a second experiment. When the dosage of isoproterenol was increased to 10 mg/kg and 2 injections of the drug were given (at 2 h intervals) pineal melatonin levels also did not exhibit a significant increase. Finally, the administration of NE at a dosage of either 2.5 or 5 mg/kg also failed to augment melatonin levels in the hamster pineal gland.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalProgress in clinical and biological research
Volume92
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'In vivo responses of the pineal gland of the Syrian hamster to isoproterenol or norepinephrine.'. Together they form a unique fingerprint.

Cite this