In vivo prostate cancer detection and grading using restriction spectrum imaging-MRI

K. C. McCammack, C. J. Kane, J. K. Parsons, N. S. White, N. M. Schenker-Ahmed, J. M. Kuperman, H. Bartsch, R. S. Desikan, R. A. Rakow-Penner, D. Adams, M. A. Liss, R. F. Mattrey, W. G. Bradley, D. J.A. Margolis, S. S. Raman, A. Shabaik, A. M. Dale, D. S. Karow

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background:Magnetic resonance imaging (MRI) is emerging as a robust, noninvasive method for detecting and characterizing prostate cancer (PCa), but limitations remain in its ability to distinguish cancerous from non-cancerous tissue. We evaluated the performance of a novel MRI technique, restriction spectrum imaging (RSI-MRI), to quantitatively detect and grade PCa compared with current standard-of-care MRI.Methods:In a retrospective evaluation of 33 patients with biopsy-proven PCa who underwent RSI-MRI and standard MRI before radical prostatectomy, receiver-operating characteristic (ROC) curves were performed for RSI-MRI and each quantitative MRI term, with area under the ROC curve (AUC) used to compare each term's ability to differentiate between PCa and normal prostate. Spearman rank-order correlations were performed to assess each term's ability to predict PCa grade in the radical prostatectomy specimens.Results:RSI-MRI demonstrated superior differentiation of PCa from normal tissue, with AUC of 0.94 and 0.85 for RSI-MRI and conventional diffusion MRI, respectively (P=0.04). RSI-MRI also demonstrated superior performance in predicting PCa aggressiveness, with Spearman rank-order correlation coefficients of 0.53 (P=0.002) and -0.42 (P=0.01) for RSI-MRI and conventional diffusion MRI, respectively, with tumor grade.Conclusions:RSI-MRI significantly improves upon current noninvasive PCa imaging and may potentially enhance its diagnosis and characterization.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Issue number2
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Urology
  • Oncology
  • Cancer Research


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