In vivo performance of combinations of autograft, demineralized bone matrix, and tricalcium phosphate in a rabbit femoral defect model

Jinku Kim, Sean McBride, David D. Dean, Victor L. Sylvia, Bruce A. Doll, Jeffrey O. Hollinger

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Large bone defects may be treated with autologous or allogeneic bone preparations. Each treatment has advantages and disadvantages; therefore, a clinically viable option for treating large (e.g., gap) bone defects may be a combination of the two. In the present study, bone repair was determined with combinations of autografts, allografts, and synthetic bone grafts using an established rabbit femoral defect model. Bilateral unicortical femoral defects were surgically prepared and treated with combinatorial bone grafts according to one of seven treatment groups. Recipient sites were retrieved at six weeks. Cellular/tissue responses and new bone formation were assessed by histology and histomorphometry. Histological analysis images indicated neither evidence of inflammatory, immune responses, tissue necrosis, nor osteolysis. Data suggested co-integration of implanted agents with host and newly formed bone. Finally, the histomorphometric data suggested that the tricalcium phosphate-based synthetic bone graft substitute allowed new bone formation that was similar to the allograft (i.e., demineralized bone matrix, DBM).

Original languageEnglish (US)
Article number035010
JournalBiomedical Materials (Bristol)
Volume9
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • Autograft
  • Bone regeneration
  • Demineralized bone matrix
  • Rabbit femoral defect
  • Tricalcium phosphate

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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