In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain

Timothy Q. Duong, Seong Gi Kim

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

In vivo measurement of cerebral arterial and venous volume fractions is important to the understanding of brain physiology and function. By using an intravascular perfluorocarbon and 19F NMR at 4.7 T, regional arterial and venous volume fractions from an intact rat brain were resolved based on the pseudodiffusion coefficients, which were (33 ± 7) x 10-3 and (0.45 ± 0.13) x 10-3 mm2/sec (mean ± SD, n = 7) for the fast- and slow-moving component, respectively. By exploiting the linear dependence of the perfluorocarbon 19F 1/T1 on the dissolved paramagnetic oxygen concentration, combined inversion-recovery and diffusion measurements were made to correlate the short T1 (high-oxygenation) component with the fast- moving component and the long T1 (low-oxygenation) component with the slow- moving component. The arterial blood volume fraction was 29 ± 7% of the total cerebral blood volume. Finally, experiments were performed in which different oxygen concentrations were inhaled to validate this technique. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)393-402
Number of pages10
JournalMagnetic Resonance in Medicine
Volume43
Issue number3
DOIs
StatePublished - 2000

Keywords

  • BOLD
  • CBV
  • F NMR
  • IVIM
  • Oxygen tension
  • Perfluorocarbon
  • Pseudodiffusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain'. Together they form a unique fingerprint.

Cite this