In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension

Enzo Bonora, Riccardo C. Bonadonna, Stefano Del Prato, Giovanni Gulli, Anna Solini, Masafumi Matsuda, Ralph A Defronzo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

This study examined whether the presence of hypertension, an insulin-resistant condition, exacerbates the defect in insulin action observed in obesity and type II diabetes mellitus. Glucose metabolism in the basal state and in response to insulin was quantitated by using the euglycemic insulin (20 mU · min-1 · m-2) clamp in combination with 3-[3H]glucose infusion and indirect calorimetry in 20 obese nondiabetic subjects (10 hypertensive and 10 normotensive), 26 type II diabetic subjects (13 hypertensive and 13 normotensive), and 11 normal nondiabetic subjects. The two groups of obese subjects and the two groups of diabetic subjects were matched for sex, age, race, body mass index, and fat distribution. Both in the basal state and during insulin infusion, glucose disposal rates (total, oxidative, and nonoxidative) were similar in obese subjects with or without hypertension. Compared with control subjects, both groups of obese subjects were markedly insulin resistant. Similarly, type II diabetic individuals, whether normotensive or hypertensive, were equally insulin resistant. The severity of insulin resistance was nearly identical in obese and diabetic groups. In diabetic subjects, the inhibitory effect of insulin on hepatic glucose output, lipolysis, and lipid oxidation was blunted compared with normal subjects. In obese subjects the ability of insulin to inhibit lipolysis and lipid oxidation was impaired. However, hypertension did not alter the suppressive effects of insulin on hepatic glucose production, plasma free fatty acid levels, or lipid oxidation in either obese or type II diabetic subjects. These results indicate that hypertension does not confer a greater severity of insulin resistance than that already is present in obesity and type II diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)764-772
Number of pages9
JournalDiabetes
Volume42
Issue number5
StatePublished - May 1993

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Insulin
Hypertension
Glucose
Lipolysis
Lipids
Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Basal Metabolism
Indirect Calorimetry
Liver
Nonesterified Fatty Acids
Body Mass Index
Fats

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Bonora, E., Bonadonna, R. C., Del Prato, S., Gulli, G., Solini, A., Matsuda, M., & Defronzo, R. A. (1993). In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. Diabetes, 42(5), 764-772.

In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. / Bonora, Enzo; Bonadonna, Riccardo C.; Del Prato, Stefano; Gulli, Giovanni; Solini, Anna; Matsuda, Masafumi; Defronzo, Ralph A.

In: Diabetes, Vol. 42, No. 5, 05.1993, p. 764-772.

Research output: Contribution to journalArticle

Bonora, E, Bonadonna, RC, Del Prato, S, Gulli, G, Solini, A, Matsuda, M & Defronzo, RA 1993, 'In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension', Diabetes, vol. 42, no. 5, pp. 764-772.
Bonora E, Bonadonna RC, Del Prato S, Gulli G, Solini A, Matsuda M et al. In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. Diabetes. 1993 May;42(5):764-772.
Bonora, Enzo ; Bonadonna, Riccardo C. ; Del Prato, Stefano ; Gulli, Giovanni ; Solini, Anna ; Matsuda, Masafumi ; Defronzo, Ralph A. / In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. In: Diabetes. 1993 ; Vol. 42, No. 5. pp. 764-772.
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