In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

Srikanth Mahankali, Yijun Liu, Yonglin Pu, Janey Wang, Chun Wen Chen, Peter T Fox, Jia Hong Gao

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalMagnetic Resonance in Medicine
Volume43
Issue number1
DOIs
StatePublished - 2000

Fingerprint

Magnetic Resonance Imaging
Intraperitoneal Injections
Glucose
Hypothalamus
Sprague Dawley Rats
Energy Intake
Animal Models
Body Weight
Food

Keywords

  • Glucose
  • Hypothalamus
  • Magnetic resonance imaging
  • Sprague- Dawley

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model. / Mahankali, Srikanth; Liu, Yijun; Pu, Yonglin; Wang, Janey; Chen, Chun Wen; Fox, Peter T; Gao, Jia Hong.

In: Magnetic Resonance in Medicine, Vol. 43, No. 1, 2000, p. 155-159.

Research output: Contribution to journalArticle

Mahankali, Srikanth ; Liu, Yijun ; Pu, Yonglin ; Wang, Janey ; Chen, Chun Wen ; Fox, Peter T ; Gao, Jia Hong. / In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model. In: Magnetic Resonance in Medicine. 2000 ; Vol. 43, No. 1. pp. 155-159.
@article{b1e2f8fcd8f645e1a51f2db132c23990,
title = "In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model",
abstract = "The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4{\%}) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.",
keywords = "Glucose, Hypothalamus, Magnetic resonance imaging, Sprague- Dawley",
author = "Srikanth Mahankali and Yijun Liu and Yonglin Pu and Janey Wang and Chen, {Chun Wen} and Fox, {Peter T} and Gao, {Jia Hong}",
year = "2000",
doi = "10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5",
language = "English (US)",
volume = "43",
pages = "155--159",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

AU - Mahankali, Srikanth

AU - Liu, Yijun

AU - Pu, Yonglin

AU - Wang, Janey

AU - Chen, Chun Wen

AU - Fox, Peter T

AU - Gao, Jia Hong

PY - 2000

Y1 - 2000

N2 - The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

AB - The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

KW - Glucose

KW - Hypothalamus

KW - Magnetic resonance imaging

KW - Sprague- Dawley

UR - http://www.scopus.com/inward/record.url?scp=0033982159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033982159&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

DO - 10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

M3 - Article

C2 - 10642744

AN - SCOPUS:0033982159

VL - 43

SP - 155

EP - 159

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 1

ER -