In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

Srikanth Mahankali; Yijun Liu; Yonglin Pu; Janey Wang; Chun Wen Chen; Peter T. Fox; Jia Hong Gao

doi:10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

Srikanth Mahankali, Yijun Liu, Yonglin Pu, Janey Wang, Chun Wen Chen, Peter T. Fox, Jia Hong Gao

Department of Radiology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T₂/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

Original language	English (US)
Pages (from-to)	155-159
Number of pages	5
Journal	Magnetic Resonance in Medicine
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5
State	Published - 2000

Keywords

Glucose
Hypothalamus
Magnetic resonance imaging
Sprague- Dawley

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

Cite this

@article{b1e2f8fcd8f645e1a51f2db132c23990,

title = "In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model",

abstract = "The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.",

keywords = "Glucose, Hypothalamus, Magnetic resonance imaging, Sprague- Dawley",

author = "Srikanth Mahankali and Yijun Liu and Yonglin Pu and Janey Wang and Chen, {Chun Wen} and Fox, {Peter T.} and Gao, {Jia Hong}",

year = "2000",

doi = "10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5",

language = "English (US)",

volume = "43",

pages = "155--159",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

AU - Mahankali, Srikanth

AU - Liu, Yijun

AU - Pu, Yonglin

AU - Wang, Janey

AU - Chen, Chun Wen

AU - Fox, Peter T.

AU - Gao, Jia Hong

PY - 2000

Y1 - 2000

N2 - The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

AB - The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

KW - Glucose

KW - Hypothalamus

KW - Magnetic resonance imaging

KW - Sprague- Dawley

UR - http://www.scopus.com/inward/record.url?scp=0033982159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033982159&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

DO - 10.1002/(SICI)1522-2594(200001)43:1<155::AID-MRM20>3.0.CO;2-5

M3 - Article

C2 - 10642744

AN - SCOPUS:0033982159

SN - 0740-3194

VL - 43

SP - 155

EP - 159

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 1

ER -

In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this