In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model

Srikanth Mahankali, Yijun Liu, Yonglin Pu, Janey Wang, Chun Wen Chen, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid- sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2/(*)-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalMagnetic Resonance in Medicine
Volume43
Issue number1
DOIs
StatePublished - 2000

Keywords

  • Glucose
  • Hypothalamus
  • Magnetic resonance imaging
  • Sprague- Dawley

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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