In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia

George Bartzokis, Po H. Lu, Stephanie B. Stewart, Bolanle Oluwadara, Andrew J. Lucas, Joanna Pantages, Erika Pratt, Jonathan E. Sherin, Lori L. Altshuler, Jim Mintz, Michael J. Gitlin, Kenneth L. Subotnik, Keith H. Nuechterlein

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Context: Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination. The hypothesis that typical and atypical medications may differentially impact brain myelination in adults with schizophrenia was previously assessed with inversion recovery (IR) images. Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one. Objective: In a follow-up reanalysis of MRI images from the original study, we used a novel method to assess whether the difference in WM volumes could be caused by a differential effect of medications on the intracortical myelination process. Design, setting, and participants: Two different male cohorts of healthy controls ranging in age from 18-35 years were compared to cohorts of subjects with schizophrenia who were treated with either oral risperidone (Ris) or fluphenazine decanoate (Fd). Main outcome measure: A novel MRI method that combines the distinct tissue contrasts provided by IR and proton density (PD) images was used to estimate intracortical myelin (ICM) volume. Results: When compared with their pooled healthy control comparison group, the two groups of schizophrenic patients differed in the frontal lobe ICM measure with the Ris group having significantly higher volume. Conclusions: The data suggest that in adults with schizophrenia antipsychotic treatment choice may be specifically and differentially impacting later-myelinating intracortical circuitry. In vivo MRI can be used to dissect subtle differences in brain tissue characteristics and thus help clarify the effect of pharmacologic treatments on developmental and pathologic processes.

Original languageEnglish (US)
Pages (from-to)322-331
Number of pages10
JournalSchizophrenia research
Volume113
Issue number2-3
DOIs
StatePublished - Sep 1 2009

Keywords

  • Age
  • Atypical
  • Development
  • Gray matter
  • Intracortical myelin
  • Lipid
  • Oligodendrocyte
  • Prevention
  • Schizophrenia
  • Second generation antipsychotic medication
  • Trajectory
  • White matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia'. Together they form a unique fingerprint.

  • Cite this

    Bartzokis, G., Lu, P. H., Stewart, S. B., Oluwadara, B., Lucas, A. J., Pantages, J., Pratt, E., Sherin, J. E., Altshuler, L. L., Mintz, J., Gitlin, M. J., Subotnik, K. L., & Nuechterlein, K. H. (2009). In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia. Schizophrenia research, 113(2-3), 322-331. https://doi.org/10.1016/j.schres.2009.06.014