In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI

George Bartzokis, David Sultzer, Jim Mintz, Lori E. Holt, Peter Marx, C. Kelly Phelan, Stephen R. Marder

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) can measure transverse relaxation rate (R2) of tissues. Although R2 is increased by tissue iron levels, R2 is not a specific measure of iron. A new method, based on the fact that ferritin (the primary tissue iron storage protein) affects R2 in a field-dependent manner, can quantify tissue iron with specificity by measuring the Field Dependent R2 Increase (FDRI). Using the FDRI method, we compared brain iron stores in frontal white matter, caudate nucleus, putamen, and globus pallidus of five male patients with Alzheimer disease (AD) and eight age and gender-matched normal controls. FDRI values were significantly higher among AD patients in the caudate and globus pallidus. The data suggest that AD may involve disturbances in brain iron metabolism and that the involvement of iron in uhe pathophysiology of age-related neurodegenerative disorders can be investigated in vivo using MRI.

Original languageEnglish (US)
Pages (from-to)480-487
Number of pages8
JournalBiological Psychiatry
Volume35
Issue number7
DOIs
StatePublished - Apr 1 1994
Externally publishedYes

Fingerprint

Alzheimer Disease
Iron
Magnetic Resonance Imaging
Brain
Globus Pallidus
Caudate Nucleus
Putamen
Ferritins
Neurodegenerative Diseases
Proteins

Keywords

  • Alzheimer's Disease
  • extrapyramidal nuclei
  • ferritin
  • field dependent transverse relaxation rate increase (FDRI)
  • Magnetic resonance imaging (MRI)
  • T relaxation time (T)

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Bartzokis, G., Sultzer, D., Mintz, J., Holt, L. E., Marx, P., Kelly Phelan, C., & Marder, S. R. (1994). In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI. Biological Psychiatry, 35(7), 480-487. https://doi.org/10.1016/0006-3223(94)90047-7

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI. / Bartzokis, George; Sultzer, David; Mintz, Jim; Holt, Lori E.; Marx, Peter; Kelly Phelan, C.; Marder, Stephen R.

In: Biological Psychiatry, Vol. 35, No. 7, 01.04.1994, p. 480-487.

Research output: Contribution to journalArticle

Bartzokis, G, Sultzer, D, Mintz, J, Holt, LE, Marx, P, Kelly Phelan, C & Marder, SR 1994, 'In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI', Biological Psychiatry, vol. 35, no. 7, pp. 480-487. https://doi.org/10.1016/0006-3223(94)90047-7
Bartzokis, George ; Sultzer, David ; Mintz, Jim ; Holt, Lori E. ; Marx, Peter ; Kelly Phelan, C. ; Marder, Stephen R. / In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI. In: Biological Psychiatry. 1994 ; Vol. 35, No. 7. pp. 480-487.
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