In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis

Barbara J. Hoeben, David S. Burgess, Jason T. McConville, Laura K. Najvar, Robert L. Talbert, Jay I. Peters, Nathan P. Wiederhold, Bradi L. Frei, John R. Graybill, Rosie Bocanegra, Kirk A. Overhoff, Prapasri Sinswat, Keith P. Johnston, Robert O. Williams

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

Original languageEnglish (US)
Pages (from-to)1552-1554
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number4
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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