In vivo administration of isoproterenol or forskolin during the light phase induces increases in the melatonin content of the Syrian hamster pineal gland without a rise in N-acetyltransferase activity

Armando Menendez-Pelaez, Gerald R. Buzzell, Keico O. Nonaka, Russel J. Reiter

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In vivo melatonin production was stimulated during the daytime in pineal glands of female Syrian hamsters following the administration of several injections of either isoproterenol, a β-receptor agonist, or forskolin, an adenylate cyclase stimulator. The large increase in melatonin following either isoproteronol or forskolin administration was not accompanied by significant changes in N-acetyltransferase (NAT) activity. The results suggest that the Syrian hamster pineal gland, as in other species, responds by producing melatonin during the light phase if the stimulus is adjusted to its particular and specific regulatory mechanisms, i.e., if β-adrenergic stimulation is continued for 4-8 h. The lack of a commensurate increase in NAT activity raises the question of the need of maximal enzymatic activity for a significant rise in melatonin production in the Syrian hamster pineal gland.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalNeuroscience Letters
Volume110
Issue number3
DOIs
StatePublished - Mar 14 1990

Keywords

  • Cholera toxin
  • Forskolin
  • Isoproterenol
  • Melatonin
  • N-acetyltransferase
  • Pineal gland
  • Syrian hamster

ASJC Scopus subject areas

  • Neuroscience(all)

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