In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits

A. L. Barry; P. C. Fuchs; S. D. Allen; S. D. Brown; J. H. Jorgensen; F. C. Tenover

doi:10.1093/jac/37.2.365

In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits

A. L. Barry, P. C. Fuchs, S. D. Allen, S. D. Brown, J. H. Jorgensen, F. C. Tenover

Research output: Contribution to journal › Article › peer-review

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Abstract

The I-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5 μg levofloxacin discs can be used with interpretive criteria of ≤12mm for resistant (MIC ≥ 8.0 mg.L) and ≥16mm for susceptible (MIC ≤ 2.0 mg/L). For quality control of levofloxacin tests, S. pneumoniae ATCC 49619 should give zones 20-25 mm in diameter and MICs 0.5-2.0 mg/L.

Original language	English (US)
Pages (from-to)	365-369
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	37
Issue number	2
DOIs	https://doi.org/10.1093/jac/37.2.365
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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abstract = "The I-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5 μg levofloxacin discs can be used with interpretive criteria of ≤12mm for resistant (MIC ≥ 8.0 mg.L) and ≥16mm for susceptible (MIC ≤ 2.0 mg/L). For quality control of levofloxacin tests, S. pneumoniae ATCC 49619 should give zones 20-25 mm in diameter and MICs 0.5-2.0 mg/L.",

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AU - Allen, S. D.

AU - Brown, S. D.

AU - Jorgensen, J. H.

AU - Tenover, F. C.

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In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits

Abstract

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