In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits

A. L. Barry, P. C. Fuchs, S. D. Allen, S. D. Brown, J. H. Jorgensen, F. C. Tenover

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The I-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5 μg levofloxacin discs can be used with interpretive criteria of ≤12mm for resistant (MIC ≥ 8.0 mg.L) and ≥16mm for susceptible (MIC ≤ 2.0 mg/L). For quality control of levofloxacin tests, S. pneumoniae ATCC 49619 should give zones 20-25 mm in diameter and MICs 0.5-2.0 mg/L.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume37
Issue number2
StatePublished - 1996
Externally publishedYes

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Levofloxacin
Ofloxacin
Streptococcus pneumoniae
Quality Control
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

Cite this

Barry, A. L., Fuchs, P. C., Allen, S. D., Brown, S. D., Jorgensen, J. H., & Tenover, F. C. (1996). In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits. Journal of Antimicrobial Chemotherapy, 37(2), 365-369.

In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin : Interpretive criteria and quality control limits. / Barry, A. L.; Fuchs, P. C.; Allen, S. D.; Brown, S. D.; Jorgensen, J. H.; Tenover, F. C.

In: Journal of Antimicrobial Chemotherapy, Vol. 37, No. 2, 1996, p. 365-369.

Research output: Contribution to journalArticle

Barry, A. L. ; Fuchs, P. C. ; Allen, S. D. ; Brown, S. D. ; Jorgensen, J. H. ; Tenover, F. C. / In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin : Interpretive criteria and quality control limits. In: Journal of Antimicrobial Chemotherapy. 1996 ; Vol. 37, No. 2. pp. 365-369.
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