In-vitro susceptibility of Streptococcus pneumoniae to the d- and I-isomers of ofloxacin: Interpretive criteria and quality control limits

A. L. Barry, P. C. Fuchs, S. D. Allen, S. D. Brown, J. H. Jorgensen, F. C. Tenover

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The I-isomer of ofloxacin (levofloxacin) was twice as active as ofloxacin and the d-isomer was inactive against 654 Streptococcus pneumoniae isolates. For disc susceptibility tests of pneumococci, 5 μg levofloxacin discs can be used with interpretive criteria of ≤12mm for resistant (MIC ≥ 8.0 mg.L) and ≥16mm for susceptible (MIC ≤ 2.0 mg/L). For quality control of levofloxacin tests, S. pneumoniae ATCC 49619 should give zones 20-25 mm in diameter and MICs 0.5-2.0 mg/L.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume37
Issue number2
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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