In vitro susceptibility of environmental Cryptococcus neoformans variety neoformans isolates from Turkey to six antifungal agents, including SCH56592 and voriconazole

S. T. Yildiran, M. A. Saracli, A. W. Fothergill, M. G. Rinaldi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The in vitro antifungal susceptibility of 27 environmental (pigeon droppings) isolates of Cryptococcus neoformans var. neoformans, isolated from throughout Turkey, to six antifungal agents (amphotericin B, flucytosine, fluconazole, voriconazole, itraconazole, and SCH56592) was studied. Voriconazole, itraconazole, and SCH56592 all showed comparable activity and were more active than the remaining three antifungal agents tested. Overall, SCH56592 was the most active agent (MIC90, 0.015 μg/ml, at both 48 and 72 h), followed by itraconazole (MIC90, 0.03 μg/ml, at both 48 and 72 h) and voriconazole (MIC90, 0.25 μg/ml, at both 48 and 72 h), respectively. Antifungal susceptibility data for environmental isolates may reflect patterns for the clinical isolates recovered from patients from the same geographic area.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume19
Issue number4
StatePublished - 2000

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Cryptococcus neoformans
Itraconazole
Antifungal Agents
Turkey
Flucytosine
Fluconazole
Columbidae
Amphotericin B
In Vitro Techniques
Voriconazole

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

In vitro susceptibility of environmental Cryptococcus neoformans variety neoformans isolates from Turkey to six antifungal agents, including SCH56592 and voriconazole. / Yildiran, S. T.; Saracli, M. A.; Fothergill, A. W.; Rinaldi, M. G.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 19, No. 4, 2000, p. 317-319.

Research output: Contribution to journalArticle

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