In vitro susceptibilities of cerebrospinal fluid isolates of Cryptococcus neoformans collected during a ten-year period against fluconazole, voriconazole and posaconazole (SCH56592)

S. T. Yildiran, A. W. Fothergill, D. A. Sutton, M. G. Rinaldi

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We investigated the in vitro susceptibilities of 213 cerebrospinal fluid isolates of Cryptococcus neoformans isolated from 192 patients through a 10-year period, 1990-99, against fluconazole, voriconazole and posaconazole (SCH56592) by using the NCCLS (National Committee for Clinical Laboratory Standards) macrodilution method, M27-A. The overall MICs50 and MICs90 of fluconazole, voriconazole and posaconazole were found to be 2 and 8 μg ml-1, ≤ 0.125 μg ml-1 (both), and ≤ 0.015 and 0.06 μg ml-1, respectively. The MIC ranges, MICs50, and MICs90 of three triazoles were also determined according to the defined year category (1990-94, 1995, 1996, 1997 and 1998-99). The MICs50 and MICs90 of each triazole remained almost unchanged and did not exhibit any sign of an upward shift during a decade (1990-99). However, a tendency for development of possible cross-resistance between the three triazoles was observed only in 1996. Meanwhile, the individual relapsing isolates (n:21) from 20 patients exhibited same, higher or, suprisingly, lower MICs, particularly against fluconazole and posaconazole.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
Issue number9-10
Publication statusPublished - Nov 30 2002



  • Antifungal susceptibility
  • Cerebrospinal fluid
  • Cryptococcus neoformans
  • Fluconazole
  • Posaconazole
  • Voriconazole

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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