In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents

Nikolaos G. Almyroudis, Deanna A. Sutton, Annette W. Fothergill, Michael G. Rinaldi, Shimon Kusne

Research output: Contribution to journalArticle

192 Scopus citations

Abstract

We evaluated the in vitro susceptibilities of 217 zygomycetes to amphotericin B, ketoconazole, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and flucytosine. The significant in vitro activity of posaconazole against several species appears to support its reported clinical efficacy. Decreased susceptibility to amphotericin B was noted with Cunninghamella bertholletiae.

Original languageEnglish (US)
Pages (from-to)2587-2590
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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