In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota; Michael Carden; John R. Graybill; Laura K. Najvar; David S. Burgess; Nathan P. Wiederhold

doi:10.1128/AAC.00538-06

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota, Michael Carden, John R. Graybill, Laura K. Najvar, David S. Burgess, Nathan P. Wiederhold

Department of Pathology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC₅₀ values), and IC₉₀ values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

Original language	English (US)
Pages (from-to)	3926-3928
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00538-06
State	Published - Nov 2006

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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title = "In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility",

abstract = "The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.",

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AU - Carden, Michael

AU - Graybill, John R.

AU - Najvar, Laura K.

AU - Burgess, David S.

AU - Wiederhold, Nathan P.

PY - 2006/11

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AB - The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

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In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Abstract

ASJC Scopus subject areas

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