In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota, Michael Carden, John R. Graybill, Laura K. Najvar, David S. Burgess, Nathan P. Wiederhold

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

Original languageEnglish (US)
Pages (from-to)3926-3928
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number11
DOIs
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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