In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Gordon Ramage; Kacy VandeWalle; Stefano P. Bachmann; Brian L. Wickes; José L. López-Ribot

doi:10.1128/AAC.46.11.3634-3636.2002

In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Gordon Ramage
, Kacy VandeWalle
, Stefano P. Bachmann
, Brian L. Wickes
, José L. López-Ribot

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

Original language	English (US)
Pages (from-to)	3634-3636
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	46
Issue number	11
DOIs	https://doi.org/10.1128/AAC.46.11.3634-3636.2002
State	Published - Nov 2002

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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abstract = "We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99\% killing at physiological concentrations.",

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AU - VandeWalle, Kacy

AU - Bachmann, Stefano P.

AU - Wickes, Brian L.

AU - López-Ribot, José L.

PY - 2002/11

Y1 - 2002/11

N2 - We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

AB - We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

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ER -

In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Abstract

ASJC Scopus subject areas

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