TY - JOUR
T1 - In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies
AU - Ramage, Gordon
AU - VandeWalle, Kacy
AU - Bachmann, Stefano P.
AU - Wickes, Brian L.
AU - López-Ribot, José L.
PY - 2002/11
Y1 - 2002/11
N2 - We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.
AB - We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.
UR - http://www.scopus.com/inward/record.url?scp=0036841154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036841154&partnerID=8YFLogxK
U2 - 10.1128/AAC.46.11.3634-3636.2002
DO - 10.1128/AAC.46.11.3634-3636.2002
M3 - Article
C2 - 12384379
AN - SCOPUS:0036841154
SN - 0066-4804
VL - 46
SP - 3634
EP - 3636
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 11
ER -