In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies

Gordon Ramage, Kacy VandeWalle, Stefano P. Bachmann, Brian L. Wickes, José L. López-Ribot

Research output: Contribution to journalArticle

200 Scopus citations

Abstract

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

Original languageEnglish (US)
Pages (from-to)3634-3636
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume46
Issue number11
DOIs
StatePublished - Nov 2002

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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