In vitro models to study the pathogenesis of endometriosis

Jason S. Griffith, Allison K. Rodgers, Robert S. Schenken

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Several in vitro models that attempt to replicate the intraperitoneal environment have been developed to study the pathogenesis of endometriosis. The chicken chorioallantotic membrane has been used, but it has not been well characterized and may introduce some species specific variables. In vitro models using human tissues include amniotic membrane, human peritoneal explants, and cell culture monolayers. These models have been used to qualitatively, quantitatively, and temporally assess attachment of endometrial cells to peritoneal mesothelial and subsequent transmesothelial invasion. These models have also been used to assess the role of cytokines in the development of the early endometriotic lesion. Two- and three dimensional invasion chamber models have been utilized to assess endometrial cell interactions with peritoneal mesothelial cells and the extracellular matrix. Invasion models are also useful to evaluate novel therapeutic approaches. This review will focus on the above models to assist reproductive scientists interested in the pathogenesis of endometriosis.

Original languageEnglish (US)
Pages (from-to)5-12
Number of pages8
JournalReproductive Sciences
Issue number1
StatePublished - Jan 2010


  • Endometriosis
  • In vitro
  • Models

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'In vitro models to study the pathogenesis of endometriosis'. Together they form a unique fingerprint.

Cite this