In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata

E. R. Oliveira; A. W. Fothergill; W. R. Kirkpatrick; B. J. Coco; T. F. Patterson; S. W. Redding

doi:10.1128/AAC.49.8.3544-3545.2005

In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata

E. R. Oliveira, A. W. Fothergill, W. R. Kirkpatrick, B. J. Coco, T. F. Patterson, S. W. Redding

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

Original language	English (US)
Pages (from-to)	3544-3545
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	8
DOIs	https://doi.org/10.1128/AAC.49.8.3544-3545.2005
State	Published - Aug 2005

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.49.8.3544-3545.2005

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abstract = "Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.",

author = "Oliveira, {E. R.} and Fothergill, {A. W.} and Kirkpatrick, {W. R.} and Coco, {B. J.} and Patterson, {T. F.} and Redding, {S. W.}",

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AU - Oliveira, E. R.

AU - Fothergill, A. W.

AU - Kirkpatrick, W. R.

AU - Coco, B. J.

AU - Patterson, T. F.

AU - Redding, S. W.

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N2 - Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

AB - Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

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In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata

Abstract

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