TY - JOUR
T1 - In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus spp.
AU - Perea, Sofia
AU - Gonzalez, Gloria
AU - Fothergill, Annette W.
AU - Kirkpatrick, William R.
AU - Rinaldi, Michael G.
AU - Patterson, Thomas F.
PY - 2002/9
Y1 - 2002/9
N2 - The interaction between caspofungin acetate and voriconazole was studied in vitro by using 48 clinical Aspergillus spp. isolates obtained from patients with invasive aspergillosis. MICs were determined by the NCCLS broth microdilution method. Synergy, defined as a fractional inhibitory concentration (FIC) index of <1, was detected in 87.5% of the interactions; an additive effect, defined as an FIC index of 1.0, was observed in 4.2% of the interactions; and a subadditive effect, defined as an FIC index of 1.0 to 2.0, was found in 8.3% of the interactions. No antagonism was observed. Animal models are required to validate the in vivo significance of these in vitro data presented for the combination of caspofungin and voriconazole.
AB - The interaction between caspofungin acetate and voriconazole was studied in vitro by using 48 clinical Aspergillus spp. isolates obtained from patients with invasive aspergillosis. MICs were determined by the NCCLS broth microdilution method. Synergy, defined as a fractional inhibitory concentration (FIC) index of <1, was detected in 87.5% of the interactions; an additive effect, defined as an FIC index of 1.0, was observed in 4.2% of the interactions; and a subadditive effect, defined as an FIC index of 1.0 to 2.0, was found in 8.3% of the interactions. No antagonism was observed. Animal models are required to validate the in vivo significance of these in vitro data presented for the combination of caspofungin and voriconazole.
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U2 - 10.1128/AAC.46.9.3039-3041.2002
DO - 10.1128/AAC.46.9.3039-3041.2002
M3 - Article
C2 - 12183266
AN - SCOPUS:0036721037
SN - 0066-4804
VL - 46
SP - 3039
EP - 3041
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 9
ER -