In vitro inhibition of cholesterol synthesis by pregnenolone in bovine corpus luteum

Ajai Haksar, E. B. Romanoff, N. Hagino, G. Pincus

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Bovine corpus luteum slices and. minces were incubated with acetate-1-14C in the presence of pregnenolone. There was a general inhibition in the utilization of acetate-1-14C as manifested, by a decreased incorporation of radioactivity into digitonin precipitable sterols, cholesterol, progesterone, and the total lipid extract of the tissue. LH which alone would stimulate the incorporation of acetate-1-14C into these substances was not able to reverse the pregnenolone-induced. inhibition. It is suggested that pregnenolone may have a role in the regulation of steroidogenesis in the corpus luteum.

Original languageEnglish (US)
Pages (from-to)405-414
Number of pages10
JournalSteroids
Volume9
Issue number4
DOIs
StatePublished - Apr 1967
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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