In vitro immune response of cells of various lymphoid tissues in (NZB x NZW)F1 mice: Evidence for abnormality of the mesenteric lymph node cells

L. K.L. Jung, R. A. Good, G. Fernandes

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Autoimmune-prone (NZB x NZW)F1 (B/W) mice have been shown to have a variety of immunologic perturbations. However, most studies have been performed with spleen cells. By using the Mishell-Dutton culture system, we examined the in vitro immune response of the various lymphoid tissue to determine whether an imbalance at a selective lymphoid site may exist in B/W mice. It was shown that the ability of mesenteric lymph node (MLN) cells of B/W mice to generate plaque-forming cells (PFC) in response to sheep red blood cells was consistently less than that of the spleen cells. This relationship held true in the aged mice. In contrast, the ability of the MLN cells of other strains not prone to develop autoimmunity to generate PFC was higher than that of the spleen cells. No significant difference in the mitogenic response of the lymphoid cells from various lymphoid tissue in the young B/W mice was seen, as compared with normal lymphoid cells from control mice. However, it was demonstrated that a relative decrease of B cells and immunoregulatory Lyt-123+ cells in the MLN in the B/W mice occurred early in life, and it was concluded that this abnormality may account for the low PFC response observed.

Original languageEnglish (US)
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Immunology
Volume132
Issue number3
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'In vitro immune response of cells of various lymphoid tissues in (NZB x NZW)F1 mice: Evidence for abnormality of the mesenteric lymph node cells'. Together they form a unique fingerprint.

Cite this