In Vitro Gonadotropin Stimulation of Bovine Sertoli Cell Ornithine Decarboxylase Activity

GARY L. FRANCIS; TIMOTHY J. TRICHE; TERI J. BROWN; HARI C. BROWN; BARRY B. BERCU

doi:10.1002/j.1939-4640.1981.tb00635.x

In Vitro Gonadotropin Stimulation of Bovine Sertoli Cell Ornithine Decarboxylase Activity

GARY L. FRANCIS, TIMOTHY J. TRICHE, TERI J. BROWN, HARI C. BROWN, BARRY B. BERCU

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The activity of ornithine decarboxylase (ODC) was determined in primary cultures of bovine Sertoli cells after gonadotropin stimulation in vitro. A significant increase in both ODC activity and putrescine content was noted 4 hours after FSH stimulation of cells derived from animals 7 to 14 days of age. Response in cells derived from animals 2 months of age was significantly less. Additionally, it was noted that both LH and hCG stimulated the ODC activity in bovine Sertoli cell preparations. These findings suggest that ODC activity In bovine Sertoli cells may be under FSH control and that LH or hCG may have significant FSH‐like effects in this system. Also, It is suggested that ODC responsiveness decreases during bovine Sertoli cell maturation. 1981 American Society of Andrology

Original language	English (US)
Pages (from-to)	312-320
Number of pages	9
Journal	Journal of Andrology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/j.1939-4640.1981.tb00635.x
State	Published - 1981
Externally published	Yes

Keywords

Sertoli cell
bovine
calf
gonadotropins
ornithine decarboxylase

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Reproductive Medicine
Endocrinology
Urology

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10.1002/j.1939-4640.1981.tb00635.x

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title = "In Vitro Gonadotropin Stimulation of Bovine Sertoli Cell Ornithine Decarboxylase Activity",

abstract = "The activity of ornithine decarboxylase (ODC) was determined in primary cultures of bovine Sertoli cells after gonadotropin stimulation in vitro. A significant increase in both ODC activity and putrescine content was noted 4 hours after FSH stimulation of cells derived from animals 7 to 14 days of age. Response in cells derived from animals 2 months of age was significantly less. Additionally, it was noted that both LH and hCG stimulated the ODC activity in bovine Sertoli cell preparations. These findings suggest that ODC activity In bovine Sertoli cells may be under FSH control and that LH or hCG may have significant FSH‐like effects in this system. Also, It is suggested that ODC responsiveness decreases during bovine Sertoli cell maturation. 1981 American Society of Andrology",

keywords = "Sertoli cell, bovine, calf, gonadotropins, ornithine decarboxylase",

author = "FRANCIS, {GARY L.} and TRICHE, {TIMOTHY J.} and BROWN, {TERI J.} and BROWN, {HARI C.} and BERCU, {BARRY B.}",

year = "1981",

doi = "10.1002/j.1939-4640.1981.tb00635.x",

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volume = "2",

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journal = "Journal of Andrology",

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AU - FRANCIS, GARY L.

AU - TRICHE, TIMOTHY J.

AU - BROWN, TERI J.

AU - BROWN, HARI C.

AU - BERCU, BARRY B.

PY - 1981

Y1 - 1981

N2 - The activity of ornithine decarboxylase (ODC) was determined in primary cultures of bovine Sertoli cells after gonadotropin stimulation in vitro. A significant increase in both ODC activity and putrescine content was noted 4 hours after FSH stimulation of cells derived from animals 7 to 14 days of age. Response in cells derived from animals 2 months of age was significantly less. Additionally, it was noted that both LH and hCG stimulated the ODC activity in bovine Sertoli cell preparations. These findings suggest that ODC activity In bovine Sertoli cells may be under FSH control and that LH or hCG may have significant FSH‐like effects in this system. Also, It is suggested that ODC responsiveness decreases during bovine Sertoli cell maturation. 1981 American Society of Andrology

AB - The activity of ornithine decarboxylase (ODC) was determined in primary cultures of bovine Sertoli cells after gonadotropin stimulation in vitro. A significant increase in both ODC activity and putrescine content was noted 4 hours after FSH stimulation of cells derived from animals 7 to 14 days of age. Response in cells derived from animals 2 months of age was significantly less. Additionally, it was noted that both LH and hCG stimulated the ODC activity in bovine Sertoli cell preparations. These findings suggest that ODC activity In bovine Sertoli cells may be under FSH control and that LH or hCG may have significant FSH‐like effects in this system. Also, It is suggested that ODC responsiveness decreases during bovine Sertoli cell maturation. 1981 American Society of Andrology

KW - Sertoli cell

KW - bovine

KW - calf

KW - gonadotropins

KW - ornithine decarboxylase

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In Vitro Gonadotropin Stimulation of Bovine Sertoli Cell Ornithine Decarboxylase Activity

Abstract

Keywords

ASJC Scopus subject areas

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