in vitro exposure to electromagnetic fields: Changes in tumour cell properties

Jerry L. Phillips, Wendell D. Winters, Loyce Rutledge

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Two human colon cancer cell lines, Colo 205 and Colo 320 DM, have been studied for their responses to 60 Hz-generated electromagnetic fields (EMF) using soft agar cloning and monoclonal antibody binding assays to assess exposure-induced changes. Cellular responses have been studied after 24 h continuous exposure of cells concurrently to four experimental conditions; i.e. no EMF (E-M-), magnetic field only (M +, 1·0 G rms), electric field only (E +, 300 mA/m2 rms), and combined electric plus magnetic fields at these intensities (E + M +). Under these conditions, both cell lines demonstrated significantly increased colony formation in soft agar and increased expression of tumor associated antigens after exposure to E + M + and to M + as compared to unexposed controls.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalInternational Journal of Radiation Biology
Volume49
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • Cell surface properties
  • Clonogenicity
  • Electromagnetic fields
  • Tumour cells

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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