Abstract
The use of a biodegradable implant system that provides a steady, controlled release of drugs or bioactive factors can be an attractive delivery vehicle of substances that can enhance repair processes in the musculoskeletal system. The present in vitro study examined the degradative characteristics and release kinetics of a 50 to 50 polylactic acid/polyglycolic acid implant, used as a carrier of trypsin inhibitor, during a 10-week period. Morphological and scanning electron microscopic examinations demonstrated that the implant degraded in a gradual, extended fashion such that by 10 weeks the implant was completely dissolved. It also was shown that the protein was released from the implant in a sigmoidal fashion with increased release between 3 and 7 weeks. More than 95% of the trypsin inhibitor originally incorporated in the implants was released during the 10-week test period. To describe further the degradation process of the implant, temporal changes in its molecular weight and surface axial strain were determined also. It was shown that in the initial 4 weeks, there was a marked decrease in molecular weight of the implants. Axial strain decreased and then increased over time, suggesting an initial period of stiffening followed by a period of degradative softening.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 272-281 |
| Number of pages | 10 |
| Journal | Clinical Orthopaedics and Related Research |
| Issue number | 315 |
| State | Published - 1995 |
Fingerprint
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
Cite this
In vitro degradation and release characteristics of biodegradable implants containing trypsin inhibitor. / Athanasiou, K. A.; Singhal, A. R.; Agrawal, C. M.; Boyan, B. D.
In: Clinical Orthopaedics and Related Research, No. 315, 1995, p. 272-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro degradation and release characteristics of biodegradable implants containing trypsin inhibitor
AU - Athanasiou, K. A.
AU - Singhal, A. R.
AU - Agrawal, C. M.
AU - Boyan, B. D.
PY - 1995
Y1 - 1995
N2 - The use of a biodegradable implant system that provides a steady, controlled release of drugs or bioactive factors can be an attractive delivery vehicle of substances that can enhance repair processes in the musculoskeletal system. The present in vitro study examined the degradative characteristics and release kinetics of a 50 to 50 polylactic acid/polyglycolic acid implant, used as a carrier of trypsin inhibitor, during a 10-week period. Morphological and scanning electron microscopic examinations demonstrated that the implant degraded in a gradual, extended fashion such that by 10 weeks the implant was completely dissolved. It also was shown that the protein was released from the implant in a sigmoidal fashion with increased release between 3 and 7 weeks. More than 95% of the trypsin inhibitor originally incorporated in the implants was released during the 10-week test period. To describe further the degradation process of the implant, temporal changes in its molecular weight and surface axial strain were determined also. It was shown that in the initial 4 weeks, there was a marked decrease in molecular weight of the implants. Axial strain decreased and then increased over time, suggesting an initial period of stiffening followed by a period of degradative softening.
AB - The use of a biodegradable implant system that provides a steady, controlled release of drugs or bioactive factors can be an attractive delivery vehicle of substances that can enhance repair processes in the musculoskeletal system. The present in vitro study examined the degradative characteristics and release kinetics of a 50 to 50 polylactic acid/polyglycolic acid implant, used as a carrier of trypsin inhibitor, during a 10-week period. Morphological and scanning electron microscopic examinations demonstrated that the implant degraded in a gradual, extended fashion such that by 10 weeks the implant was completely dissolved. It also was shown that the protein was released from the implant in a sigmoidal fashion with increased release between 3 and 7 weeks. More than 95% of the trypsin inhibitor originally incorporated in the implants was released during the 10-week test period. To describe further the degradation process of the implant, temporal changes in its molecular weight and surface axial strain were determined also. It was shown that in the initial 4 weeks, there was a marked decrease in molecular weight of the implants. Axial strain decreased and then increased over time, suggesting an initial period of stiffening followed by a period of degradative softening.
UR - http://www.scopus.com/inward/record.url?scp=0029041386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029041386&partnerID=8YFLogxK
M3 - Article
C2 - 7634681
AN - SCOPUS:0029041386
SP - 272
EP - 281
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
SN - 0009-921X
IS - 315
ER -