In vitro complement consumption by contrast materials and analogues: Reactors vs. nonreactors

Robert L. Siegle, Phil Lieberman, Muriel C. Rice

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Blood samples from previous contrast reactors and nonreactor controls were incubated with diatrizoate and several contrast analogues. Total complement levels were assayed. All the agents caused complement activation generally proportional to their concentration. Reactors’ sera responded to lower concentrations of contrast or analogues than did control sera. Such studies might be of value in predicting contrast reactors.

Original languageEnglish (US)
Pages (from-to)387-389
Number of pages3
JournalInvestigative Radiology
Volume18
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • 3-acetamido benzoate
  • Complement activation
  • Contrast reaction
  • Deiodinated diatrizoate
  • Diatrizoate
  • Metrizamide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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