In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

N. K. Mary; C. R. Achuthan; B. H. Babu; J. Padikkala

doi:10.1016/S0378-8741(03)00119-3

In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

N. K. Mary, C. R. Achuthan, B. H. Babu, J. Padikkala

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The methanolic extract of Hemidesmus indicus (L) R.Br. (Asclepiadaceae) roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 217.5μg/ml. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.5 and 287.5μg/ml, respectively. The intravenous administration of this extract (5mg/kg body weight) in rabbits delayed the plasma recalcification time and enhanced the release of lipoprotein lipase enzyme significantly. The extract also inhibited ADP-induced platelet aggregation in vitro (50-250μg), which was comparable to commercial heparin.

Original language	English (US)
Pages (from-to)	187-191
Number of pages	5
Journal	Journal of Ethnopharmacology
Volume	87
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(03)00119-3
State	Published - Aug 1 2003
Externally published	Yes

Keywords

Anticoagulant activity
Antioxidant activity
Antiplatelet aggregation
Antithrombotic activity
Hemidesmus indicus
Lipoprotein lipase

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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10.1016/S0378-8741(03)00119-3

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title = "In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.",

abstract = "The methanolic extract of Hemidesmus indicus (L) R.Br. (Asclepiadaceae) roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 217.5μg/ml. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.5 and 287.5μg/ml, respectively. The intravenous administration of this extract (5mg/kg body weight) in rabbits delayed the plasma recalcification time and enhanced the release of lipoprotein lipase enzyme significantly. The extract also inhibited ADP-induced platelet aggregation in vitro (50-250μg), which was comparable to commercial heparin.",

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AU - Achuthan, C. R.

AU - Babu, B. H.

AU - Padikkala, J.

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KW - Antioxidant activity

KW - Antiplatelet aggregation

KW - Antithrombotic activity

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KW - Lipoprotein lipase

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In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

Abstract

Keywords

ASJC Scopus subject areas

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