In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br.

N. K. Mary, C. R. Achuthan, B. H. Babu, J. Padikkala

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The methanolic extract of Hemidesmus indicus (L) R.Br. (Asclepiadaceae) roots was found to inhibit lipid peroxidation and scavenge hydroxyl and superoxide radicals in vitro. The amount required for 50% inhibition of lipid peroxide formation was 217.5μg/ml. The concentrations needed to scavenge hydroxyl and superoxide radicals were 73.5 and 287.5μg/ml, respectively. The intravenous administration of this extract (5mg/kg body weight) in rabbits delayed the plasma recalcification time and enhanced the release of lipoprotein lipase enzyme significantly. The extract also inhibited ADP-induced platelet aggregation in vitro (50-250μg), which was comparable to commercial heparin.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalJournal of Ethnopharmacology
Volume87
Issue number2-3
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Anticoagulant activity
  • Antioxidant activity
  • Antiplatelet aggregation
  • Antithrombotic activity
  • Hemidesmus indicus
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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