In vitro activity of voriconazole against selected fungi

M. R. McGinnis, L. Pasarell, D. A. Sutton, A. W. Fothergill, C. R. Cooper, M. G. Rinaldi

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Fifty-nine isolates consisting of 14 genera and 33 species of ascomycetes, basidiomycetes, and zygomycetes were tested against amphotericin B, fluconazole, itraconazole and voriconazole using an in vitro modified macrobroth dilution procedure based upon the NCCLS M27-A standard method for yeasts. The triazoles voriconazole and itraconazole had similar MIC values, except for Acremonium alabamensis, A. strictum, Fusarium oxysporum, F. solani and Wangiella dermatitidis, which had substantially lower voriconazole MIC values. Voriconazole MIC values were lower than those for itraconazole for the 17 species of Trichosporon tested. Fluconazole had high MIC values, often greater than 128 μg ml-1.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalMedical mycology
Volume36
Issue number4
DOIs
StatePublished - Aug 1 1998

Keywords

  • Amphotericin B
  • Fluconazole
  • Itraconazole
  • Voriconazole

ASJC Scopus subject areas

  • Infectious Diseases

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