In vitro activity of voriconazole against selected fungi

M. R. McGinnis, L. Pasarell, D. A. Sutton, A. W. Fothergill, C. R. Cooper, M. G. Rinaldi

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Fifty-nine isolates consisting of 14 genera and 33 species of ascomycetes, basidiomycetes, and zygomycetes were tested against amphotericin B, fluconazole, itraconazole and voriconazole using an in vitro modified macrobroth dilution procedure based upon the NCCLS M27-A standard method for yeasts. The triazoles voriconazole and itraconazole had similar MIC values, except for Acremonium alabamensis, A. strictum, Fusarium oxysporum, F. solani and Wangiella dermatitidis, which had substantially lower voriconazole MIC values. Voriconazole MIC values were lower than those for itraconazole for the 17 species of Trichosporon tested. Fluconazole had high MIC values, often greater than 128 μg ml-1.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalMedical Mycology
Volume36
Issue number4
DOIs
StatePublished - Aug 1998

Fingerprint

itraconazole
Itraconazole
fluconazole
Fungi
fungi
Fluconazole
Acremonium strictum
Exophiala dermatitidis
Trichosporon
Acremonium
triazoles
Fusarium solani
Exophiala
amphotericin B
Fusarium oxysporum
Basidiomycota
Ascomycota
Triazoles
Fusarium
Amphotericin B

Keywords

  • Amphotericin B
  • Fluconazole
  • Itraconazole
  • Voriconazole

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

McGinnis, M. R., Pasarell, L., Sutton, D. A., Fothergill, A. W., Cooper, C. R., & Rinaldi, M. G. (1998). In vitro activity of voriconazole against selected fungi. Medical Mycology, 36(4), 239-242. https://doi.org/10.1046/j.1365-280X.1998.00153.x

In vitro activity of voriconazole against selected fungi. / McGinnis, M. R.; Pasarell, L.; Sutton, D. A.; Fothergill, A. W.; Cooper, C. R.; Rinaldi, M. G.

In: Medical Mycology, Vol. 36, No. 4, 08.1998, p. 239-242.

Research output: Contribution to journalArticle

McGinnis, MR, Pasarell, L, Sutton, DA, Fothergill, AW, Cooper, CR & Rinaldi, MG 1998, 'In vitro activity of voriconazole against selected fungi', Medical Mycology, vol. 36, no. 4, pp. 239-242. https://doi.org/10.1046/j.1365-280X.1998.00153.x
McGinnis MR, Pasarell L, Sutton DA, Fothergill AW, Cooper CR, Rinaldi MG. In vitro activity of voriconazole against selected fungi. Medical Mycology. 1998 Aug;36(4):239-242. https://doi.org/10.1046/j.1365-280X.1998.00153.x
McGinnis, M. R. ; Pasarell, L. ; Sutton, D. A. ; Fothergill, A. W. ; Cooper, C. R. ; Rinaldi, M. G. / In vitro activity of voriconazole against selected fungi. In: Medical Mycology. 1998 ; Vol. 36, No. 4. pp. 239-242.
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