A broth macrodilution method, performed as recommended by the National Committee for Clinical Laboratory Standards, was used for comparative testing of the new echinocandin antifungal agent MK-0991 and fluconazole against 50 yeast isolates belonging to 12 species of Candida. MK-0991 was shown to be highly effective against both fluconazole-susceptible and -resistant Candida spp., yielding minimum inhibitory concentrations ranging from ≤ 0.19 to 0.78 μg/ml. Fungicidal activity was exerted at ≤ 1.5 μg/ml for 73% of the isolates tested. This study suggests that MK-0991 has significant potential for clinical development.
|Original language||English (US)|
|Number of pages||3|
|Journal||European Journal of Clinical Microbiology and Infectious Diseases|
|Publication status||Published - Nov 22 1999|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases