In vitro activity of itraconazole against fluconazole-susceptible and - resistant Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus

F. Barchiesi, A. L. Colombo, D. A. McGough, A. W. Fothergill, M. G. Rinaldi

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

A broth macrodilution technique, which was performed by following the recommendations provided by the National Committee for Clinical Laboratory Standards (document M27-P), was applied to study the in vitro activity of itraconazole against fluconazole-susceptible and -resistant Candida albicans isolates from the oral cavities of 100 patients infected with human immunodeficiency virus. The in vitro data demonstrated that itraconazole had good activity against the tested isolates; for 90% of all strains of C. albicans, MICs were 1 μg/ml, and only one isolate was highly resistant to this triazole (MIC, >16 μg/ml). However, the itraconazole MICs for the fluconazole-susceptible isolates were significantly lower than those for the fluconazole-resistant isolates; the MICs for 50 and 90% of the isolates tested were ≤0.03 and 0.25 μg/ml, respectively, for the fluconazole- susceptible isolates and 0.5 and 1 μg/ml, respectively, for the fluconazole- resistant isolates (P = 0.00001). Our findings could be of clinical relevance because human immunodeficiency virus-infected patients who fail fluconazole therapy for oral and/or esophageal candidiasis may require itraconazole at doses higher than those used in standard therapy.

Original languageEnglish (US)
Pages (from-to)1530-1533
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume38
Issue number7
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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