In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance

Stefano P. Bachmann, Thomas F. Patterson, José L. López-Ribot

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Caspofungin inhibits the synthesis of 1,3-β-D-glucan, a key step in fungal cell wall biosynthesis. Here we report on its potent in vitro activity (MIC at which 90% of the isolates tested are inhibited = 1 μg per ml of RPMI medium) against 32 Candida albicans fluconazole-susceptible and -resistant clinical isolates irrespective of the underlying resistance mechanism (alterations in ERG11 and/or upregulation of MDR and CDR genes encoding efflux pumps) and provide further evidence that caspofungin is not a substrate for multidrug transporters.

Original languageEnglish (US)
Pages (from-to)2228-2230
Number of pages3
JournalJournal of clinical microbiology
Volume40
Issue number6
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Microbiology (medical)

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