In vitro activities of the oxazolidinone antibiotics U-100592 and U- 100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species

J. H. Jorgensen, M. L. McElmeel, C. W. Trippy

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66 Scopus citations


U-100592 and U-100766 are closely related antibiotics of the oxazolidinone class. Their in vitro activities were determined against 100 isolates of Staphylococcus aureus and 100 isolates of coagulase-negative Staphylococcus species by broth and agar dilution test methods. The MICs of both compounds by either test method at which 50 and 90% of isolates are inhibited were 2 and 4 μg/ml, respectively, for S. aureus and 1 to 2 μg/ml for coagulase-negative staphylococci. Time-kill assays with selected strains indicated a primarily bacteriostatic effect against staphylococci.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number2
StatePublished - Mar 20 1997


ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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