Abstract
U-100592 and U-100766 are closely related antibiotics of the oxazolidinone class. Their in vitro activities were determined against 100 isolates of Staphylococcus aureus and 100 isolates of coagulase-negative Staphylococcus species by broth and agar dilution test methods. The MICs of both compounds by either test method at which 50 and 90% of isolates are inhibited were 2 and 4 μg/ml, respectively, for S. aureus and 1 to 2 μg/ml for coagulase-negative staphylococci. Time-kill assays with selected strains indicated a primarily bacteriostatic effect against staphylococci.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-467 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 41 |
| Issue number | 2 |
| State | Published - 1997 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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In vitro activities of the oxazolidinone antibiotics U-100592 and U- 100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species. / Jorgensen, J. H.; McElmeel, M. L.; Trippy, C. W.
In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 2, 1997, p. 465-467.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro activities of the oxazolidinone antibiotics U-100592 and U- 100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species
AU - Jorgensen, J. H.
AU - McElmeel, M. L.
AU - Trippy, C. W.
PY - 1997
Y1 - 1997
N2 - U-100592 and U-100766 are closely related antibiotics of the oxazolidinone class. Their in vitro activities were determined against 100 isolates of Staphylococcus aureus and 100 isolates of coagulase-negative Staphylococcus species by broth and agar dilution test methods. The MICs of both compounds by either test method at which 50 and 90% of isolates are inhibited were 2 and 4 μg/ml, respectively, for S. aureus and 1 to 2 μg/ml for coagulase-negative staphylococci. Time-kill assays with selected strains indicated a primarily bacteriostatic effect against staphylococci.
AB - U-100592 and U-100766 are closely related antibiotics of the oxazolidinone class. Their in vitro activities were determined against 100 isolates of Staphylococcus aureus and 100 isolates of coagulase-negative Staphylococcus species by broth and agar dilution test methods. The MICs of both compounds by either test method at which 50 and 90% of isolates are inhibited were 2 and 4 μg/ml, respectively, for S. aureus and 1 to 2 μg/ml for coagulase-negative staphylococci. Time-kill assays with selected strains indicated a primarily bacteriostatic effect against staphylococci.
UR - http://www.scopus.com/inward/record.url?scp=0031046150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031046150&partnerID=8YFLogxK
M3 - Article
C2 - 9021209
AN - SCOPUS:0031046150
VL - 41
SP - 465
EP - 467
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 2
ER -