In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages

Gloria M. González, Rolando Tijerina, Deanna A. Sutton, John R. Graybill, Michael G. Rinaldi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We investigated the susceptibilities of hyphal, mixed hyphal, ungerminated arthroconidial, and germinated arthroconidial populations of Coccidioides immitis to lipid formulations of amphotericin B and nystatin and their conventional preparations, utilizing the National Committee for Clinical Laboratory Standards M38-P broth macrodilution method. The differences in effects of the three different growth stages of the saprobic phase of C. immitis on the MIC/minimum lethal concentration (MLC) ratio were not statistically significant for any of the antifungal agents tested. These results suggest that either inocula could be used for in vitro susceptibility studies with C. immitis.

Original languageEnglish (US)
Pages (from-to)1583-1585
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume46
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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