In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages

Gloria M. González; Rolando Tijerina; Deanna A. Sutton; John R. Graybill; Michael G. Rinaldi

doi:10.1128/AAC.46.5.1583-1585.2002

In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages

Gloria M. González, Rolando Tijerina, Deanna A. Sutton, John R. Graybill, Michael G. Rinaldi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We investigated the susceptibilities of hyphal, mixed hyphal, ungerminated arthroconidial, and germinated arthroconidial populations of Coccidioides immitis to lipid formulations of amphotericin B and nystatin and their conventional preparations, utilizing the National Committee for Clinical Laboratory Standards M38-P broth macrodilution method. The differences in effects of the three different growth stages of the saprobic phase of C. immitis on the MIC/minimum lethal concentration (MLC) ratio were not statistically significant for any of the antifungal agents tested. These results suggest that either inocula could be used for in vitro susceptibility studies with C. immitis.

Original language	English (US)
Pages (from-to)	1583-1585
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	46
Issue number	5
DOIs	https://doi.org/10.1128/AAC.46.5.1583-1585.2002
State	Published - 2002

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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In vitro activities of free and lipid formulations of amphotericin B and nystatin against clinical isolates of Coccidioides immitis at various saprobic stages. / González, Gloria M.; Tijerina, Rolando; Sutton, Deanna A.; Graybill, John R.; Rinaldi, Michael G.

In: Antimicrobial agents and chemotherapy, Vol. 46, No. 5, 2002, p. 1583-1585.

Research output: Contribution to journal › Article › peer-review

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abstract = "We investigated the susceptibilities of hyphal, mixed hyphal, ungerminated arthroconidial, and germinated arthroconidial populations of Coccidioides immitis to lipid formulations of amphotericin B and nystatin and their conventional preparations, utilizing the National Committee for Clinical Laboratory Standards M38-P broth macrodilution method. The differences in effects of the three different growth stages of the saprobic phase of C. immitis on the MIC/minimum lethal concentration (MLC) ratio were not statistically significant for any of the antifungal agents tested. These results suggest that either inocula could be used for in vitro susceptibility studies with C. immitis.",

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