In vitro acetylation of plasma proteins, enzymes and DNA by aspirin

R. Neal Pinckard; David Hawkins; Richard S. Farr

doi:10.1038/219068a0

In vitro acetylation of plasma proteins, enzymes and DNA by aspirin

R. Neal Pinckard, David Hawkins, Richard S. Farr

Research output: Contribution to journal › Letter › peer-review

148 Scopus citations

Abstract

HUMAN serum albumin (HSA) is permanently altered after exposure to therapeutic concentrations of acetylsalicylic acid (ASA, aspirin) either in vitro or in vivo1-3. Recently we showed that this structural alteration was the result of the acetylation of the HSA molecule by aspirin4,5. Because the acetylation of HSA by aspirin could occur by aminolysis resulting in an N-acetyl-HSA derivative, we decided to determine whether aspirin could acetylate other biological materials. We now report that aspirin acetylates a variety of body constituents in vitro.

Original language	English (US)
Pages (from-to)	68-69
Number of pages	2
Journal	Nature
Volume	219
Issue number	5149
DOIs	https://doi.org/10.1038/219068a0
State	Published - Dec 1 1968
Externally published	Yes

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AU - Hawkins, David

AU - Farr, Richard S.

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N2 - HUMAN serum albumin (HSA) is permanently altered after exposure to therapeutic concentrations of acetylsalicylic acid (ASA, aspirin) either in vitro or in vivo1-3. Recently we showed that this structural alteration was the result of the acetylation of the HSA molecule by aspirin4,5. Because the acetylation of HSA by aspirin could occur by aminolysis resulting in an N-acetyl-HSA derivative, we decided to determine whether aspirin could acetylate other biological materials. We now report that aspirin acetylates a variety of body constituents in vitro.

AB - HUMAN serum albumin (HSA) is permanently altered after exposure to therapeutic concentrations of acetylsalicylic acid (ASA, aspirin) either in vitro or in vivo1-3. Recently we showed that this structural alteration was the result of the acetylation of the HSA molecule by aspirin4,5. Because the acetylation of HSA by aspirin could occur by aminolysis resulting in an N-acetyl-HSA derivative, we decided to determine whether aspirin could acetylate other biological materials. We now report that aspirin acetylates a variety of body constituents in vitro.

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