TY - JOUR
T1 - In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices
AU - Mensinkai, Poornima K.
AU - Ccahuana-Vasquez, Renzo A.
AU - Chedjieu, Irene
AU - Amaechi, Bennett T.
AU - Mackey, Allen C.
AU - Walker, Trenton J.
AU - Blanken, Douglas D.
AU - Karlinsey, Robert L.
N1 - Funding Information:
Acknowledgments This project was supported by a Small Business Innovation Research grant (R43DE020998) from the National Institutes of Health’s Office of the Director and National Institute of Dental & Craniofacial Research. We thank GlaxoSmithKline (especially Dr. Christabel Fowler) for providing the dentifrices used in this study.
PY - 2012/8
Y1 - 2012/8
N2 - The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Subjects (N = 30) in this randomized, three-phase, 28-day, crossover study served as their own control. Each participant wore a customized orthodontic appliance attached to a mandibular molar and contained one tooth block with caries-like lesion. For each phase, participants engaged in twice-daily brushing for 2 min with one of the following dentifrices: 500 ppm F, 500 ppm F plus functionalized β-tricalcium phosphate (fTCP), and a clinically proven 1,100 ppm F. After each phase, appliances were removed, and specimens were analyzed using surface microhardness (SMH), transverse microradiography (TMR), and cross-sectional microhardness (CSMH). Statistically significant (p<0. 05) remineralization of white-spot lesions relative to baseline occurred for each dentifrice as determined with SMH and TMR. No significant differences (p>0. 05) in SMH were found among the three groups, but trending revealed the 500 ppm F plus fTCP produced 26% and 27% greater SMH recovery relative to 500 and 1,100 ppm F, respectively. Similarly, no significant differences (p>0. 05) in TMR were found among the groups. However, the 500 ppm F plus fTCP dentifrice produced 10% and 38% greater mineral recovery relative to 500 and 1,100 ppm F, respectively, while reducing the lesion depth 30% and 52%, respectively. Significant differences (p<0. 05) in CSMH existed among the three dentifice groups at different enamel depths, but statistical differences (p<0. 05) in relative lesion size were only found between 500 ppm F plus fTCP and 500 ppm F. The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.
AB - The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. Subjects (N = 30) in this randomized, three-phase, 28-day, crossover study served as their own control. Each participant wore a customized orthodontic appliance attached to a mandibular molar and contained one tooth block with caries-like lesion. For each phase, participants engaged in twice-daily brushing for 2 min with one of the following dentifrices: 500 ppm F, 500 ppm F plus functionalized β-tricalcium phosphate (fTCP), and a clinically proven 1,100 ppm F. After each phase, appliances were removed, and specimens were analyzed using surface microhardness (SMH), transverse microradiography (TMR), and cross-sectional microhardness (CSMH). Statistically significant (p<0. 05) remineralization of white-spot lesions relative to baseline occurred for each dentifrice as determined with SMH and TMR. No significant differences (p>0. 05) in SMH were found among the three groups, but trending revealed the 500 ppm F plus fTCP produced 26% and 27% greater SMH recovery relative to 500 and 1,100 ppm F, respectively. Similarly, no significant differences (p>0. 05) in TMR were found among the groups. However, the 500 ppm F plus fTCP dentifrice produced 10% and 38% greater mineral recovery relative to 500 and 1,100 ppm F, respectively, while reducing the lesion depth 30% and 52%, respectively. Significant differences (p<0. 05) in CSMH existed among the three dentifice groups at different enamel depths, but statistical differences (p<0. 05) in relative lesion size were only found between 500 ppm F plus fTCP and 500 ppm F. The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.
KW - Caries
KW - Dentifrice
KW - Fluoride
KW - Remineralization
KW - fTCP
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UR - http://www.scopus.com/inward/citedby.url?scp=84864278493&partnerID=8YFLogxK
U2 - 10.1007/s00784-011-0591-2
DO - 10.1007/s00784-011-0591-2
M3 - Article
C2 - 21750917
AN - SCOPUS:84864278493
SN - 1432-6981
VL - 16
SP - 1007
EP - 1014
JO - Clinical Oral Investigations
JF - Clinical Oral Investigations
IS - 4
ER -