Imunologia do transtorno bipolar

Translated title of the contribution: Immunology of bipolar disorder

Izabela Guimarães Barbosa, Rodrigo Barreto Huguet, Fernando Silva Neves, Moisés Evandro Bauer, Antônio Lúcio Teixeira

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Objective: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. Methods: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. Results: Twenty eight works were found. Six studies investigated immune responserelated genes; five, auto-antibodies; four, leukocyte population; 13, cytokines and/or immune-related molecules; six, leukocytes in vitro. Conclusions: Although there is evidence in the literature correlating affective disorders with immune parameters, the results are still inconclusive. Bipolar disorder seems to be associated with increased levels of auto-antibodies as well as with a trend for increased immune activation with production of pro-inflammatory cytokines and reduction of the anti-inflammatory parameters.

Translated title of the contributionImmunology of bipolar disorder
Original languagePortuguese
Pages (from-to)52-59
Number of pages8
JournalJornal Brasileiro de Psiquiatria
Issue number1
StatePublished - Jan 2009
Externally publishedYes


  • Bipolar disorder
  • Chemokines
  • Cytokines
  • Immunology
  • Interferon and tumor necrosis factor-α
  • Interleukins

ASJC Scopus subject areas

  • Psychiatry and Mental health


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