Abstract
Objective: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. Methods: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. Results: Twenty eight works were found. Six studies investigated immune responserelated genes; five, auto-antibodies; four, leukocyte population; 13, cytokines and/or immune-related molecules; six, leukocytes in vitro. Conclusions: Although there is evidence in the literature correlating affective disorders with immune parameters, the results are still inconclusive. Bipolar disorder seems to be associated with increased levels of auto-antibodies as well as with a trend for increased immune activation with production of pro-inflammatory cytokines and reduction of the anti-inflammatory parameters.
| Translated title of the contribution | Immunology of bipolar disorder |
|---|---|
| Original language | Portuguese |
| Pages (from-to) | 52-59 |
| Number of pages | 8 |
| Journal | Jornal Brasileiro de Psiquiatria |
| Volume | 58 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2009 |
| Externally published | Yes |
Keywords
- Bipolar disorder
- Chemokines
- Cytokines
- Immunology
- Interferon and tumor necrosis factor-α
- Interleukins
ASJC Scopus subject areas
- Psychiatry and Mental health