TY - JOUR
T1 - Impulsivity in children and adolescents with mood disorders and unaffected offspring of bipolar parents
AU - Sanches, Marsal
AU - Scott-Gurnell, Kathy
AU - Patel, Anita
AU - Caetano, Sheila C.
AU - Zunta-Soares, Giovana B.
AU - Hatch, John P
AU - Olvera, Rene
AU - Swann, Alan C.
AU - Soares, Jair C.
N1 - Funding Information:
M.S. has received research grants from Janssen Pharmaceuticals; A.C.S serves on a DSMB for Teva Pharmaceuticals, has received research support from Elan Pharmaceuticals, and has acted as a consultant and speaker for Merck and Sanofi-Aventis. J.C.S. has received research grants from BMS, Forest, Merck; he received speaker’s fees from Pfizer and Abbott. None of these sources directly supported or influenced this project. No other authors received financial support relevant to this project.
Funding Information:
This research was partly supported by NARSAD , MH 69774, RR 20571 .
PY - 2014/8
Y1 - 2014/8
N2 - Objective: Increased impulsivity seems to be present across all phases of bipolar disorder (BD). Impulsivity may therefore represent an endophenotype for BD, if it is also found among normal individuals at high genetic risk for mood disorders. In this study, we assessed impulsivity across four different groups of children and adolescents: patients with BD, major depressive disorder (MDD) patients, unaffected offspring of bipolar parents (UO), and healthy controls (HC). Subjects and Methods 52 patients with BD, 31 with MDD, 20 UO, and 45 HC completed the Barratt Impulsiveness Scale (BIS-11), an instrument designed to measure trait impulsivity. Results: UO displayed significantly higher total BIS-11 impulsivity scores than HC (p = 0.02) but lower scores than BD patients (F = 27.12, p < 0.01). Multiple comparison analysis revealed higher BIS-11 total scores among BD patients when compared to HC (p < 0.01) and UO (p < 0.01). MDD patients had higher BIS-11 scores when compared to HC (p < 0.01). Differences between MDD patients and UO, as well as between MDD and BD patients, were not statistically significant. Conclusion: Our findings suggest that trait impulsivity is increased among children and adolescents with mood disorders, as well as in unaffected individuals at high genetic risk for BD.
AB - Objective: Increased impulsivity seems to be present across all phases of bipolar disorder (BD). Impulsivity may therefore represent an endophenotype for BD, if it is also found among normal individuals at high genetic risk for mood disorders. In this study, we assessed impulsivity across four different groups of children and adolescents: patients with BD, major depressive disorder (MDD) patients, unaffected offspring of bipolar parents (UO), and healthy controls (HC). Subjects and Methods 52 patients with BD, 31 with MDD, 20 UO, and 45 HC completed the Barratt Impulsiveness Scale (BIS-11), an instrument designed to measure trait impulsivity. Results: UO displayed significantly higher total BIS-11 impulsivity scores than HC (p = 0.02) but lower scores than BD patients (F = 27.12, p < 0.01). Multiple comparison analysis revealed higher BIS-11 total scores among BD patients when compared to HC (p < 0.01) and UO (p < 0.01). MDD patients had higher BIS-11 scores when compared to HC (p < 0.01). Differences between MDD patients and UO, as well as between MDD and BD patients, were not statistically significant. Conclusion: Our findings suggest that trait impulsivity is increased among children and adolescents with mood disorders, as well as in unaffected individuals at high genetic risk for BD.
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U2 - 10.1016/j.comppsych.2014.04.018
DO - 10.1016/j.comppsych.2014.04.018
M3 - Article
C2 - 24889339
AN - SCOPUS:84904719830
SN - 0010-440X
VL - 55
SP - 1337
EP - 1341
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
IS - 6
ER -