Improving biomaterials from a cellular point of view

V. G. Varanasi, T. Vallortigara, P. M. Loomer, E. Saiz, A. P. Tomsia, S. J. Marshall, G. W. Marshall

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Bioactive glass (6P55), used for coating Ti/Ti-alloy, was tested for its in vitro behavior in a comparative study with commercial Bioglass™ (45S5) and commercial titanium alloy (Ti6Al4V). In vitro testing included pH and dissolution rate determination in simulated body fluid (SBF) along with in vitro cyto-compatibility testing. Similar dissolution behavior was seen for 6P55 and 45S5, demonstrating t1/2 dependence and maximum pH of approximately 8.1 after 10 days of immersion. The dissolution rate of these glasses approached 0 after 15 days of immersion, which resulted in pH stabilization at less than 7.5. Cell culture studies showed that both glasses behaved in a similar fashion after 16 hours in culture. Both glasses had an increase in cell numbers of approximately 200-250%, whereas Ti6Al4V had a less pronounced cell number increase (∼ 180%) relative to initial cell seeding density.

Original languageEnglish (US)
Title of host publicationMechanotransduction and Engineered Cell-Surface Interactions
PublisherMaterials Research Society
Number of pages7
ISBN (Print)1558998829, 9781558998827
StatePublished - 2006
Externally publishedYes
Event2006 MRS Spring Meeting - San Francisco, CA, United States
Duration: Apr 17 2006Apr 21 2006

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Conference2006 MRS Spring Meeting
CountryUnited States
CitySan Francisco, CA

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Improving biomaterials from a cellular point of view'. Together they form a unique fingerprint.

  • Cite this

    Varanasi, V. G., Vallortigara, T., Loomer, P. M., Saiz, E., Tomsia, A. P., Marshall, S. J., & Marshall, G. W. (2006). Improving biomaterials from a cellular point of view. In Mechanotransduction and Engineered Cell-Surface Interactions (pp. 13-19). (Materials Research Society Symposium Proceedings; Vol. 925). Materials Research Society.