Improved assays for hydralazine and hydralazine pyruvic acid hydrazone in human plasma

T. M. Ludden, L. K. Ludden, J. L. McNay, H. B. Skrdlant, P. J. Swaggerty, A. M.M. Shepherd

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Previous determinations of hydralazine and hydralazine pyruvic acid hydrazone based on derivatization and high-performance liquid chromatography have been modified to improve the detection limits of the hydralazine assay and the selectivity of the hydralazine pyruvic acid hydrazone technique. The lower limits of determinations of hydralazine and hydralazine pyruvic acid hydrazone are 2 and 25 ng ml-1, respectively. The application of this technique to the determination of these substances in human plasma is demonstrated.

Original languageEnglish (US)
Pages (from-to)297-304
Number of pages8
JournalAnalytica Chimica Acta
Volume120
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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