Important role of CCR2 in a murine model of coronary vasculitis

Hernan G. Martinez, Marlon P. Quinones, Fabio Jimenez, Carlos Estrada, Kassandra M. Clark, Kazuo Suzuki, Noriko Miura, Naohito Ohno, Sunil K. Ahuja, Seema S. Ahuja

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Chemokines and their receptors play a role in the innate immune response as well as in the disruption of the balance between pro-inflammatory Th17 cells and regulatory T cells (Treg), underlying the pathogenesis of coronary vasculitis in Kawasaki disease (KD).Results: Here we show that genetic inactivation of chemokine receptor (CCR)-2 is protective against the induction of aortic and coronary vasculitis following injection of Candida albicans water-soluble cell wall extracts (CAWS). Mechanistically, both T and B cells were required for the induction of vasculitis, a role that was directly modulated by CCR2. CAWS administration promoted mobilization of CCR2-dependent inflammatory monocytes (iMo) from the bone marrow (BM) to the periphery as well as production of IL-6. IL-6 was likely to contribute to the depletion of Treg and expansion of Th17 cells in CAWS-injected Ccr2+/+ mice, processes that were ameliorated following the genetic inactivation of CCR2.Conclusion: Collectively, our findings provide novel insights into the role of CCR2 in the pathogenesis of vasculitis as seen in KD and highlight novel therapeutic targets, specifically for individuals resistant to first-line treatments.

Original languageEnglish (US)
Article number56
JournalBMC Immunology
Volume13
DOIs
StatePublished - Oct 17 2012

Keywords

  • CCR2
  • Coronary vasculitis
  • Treg
  • Treg/Th17 imbalance

ASJC Scopus subject areas

  • Immunology

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