Importance of the caspase cleavage site in amyloid-β protein precursor

Dale E. Bredesen, Varghese John, Veronica Galvan

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalJournal of Alzheimer's Disease
Volume22
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Alzheimer's disease
  • amyloid-β peptide caspases
  • transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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