Importance of Candida species other than Candida albicans as opportunistic pathogens

D. C. Coleman, M. G. Rinaldi, K. A. Haynes, J. H. Rex, R. C. Summerbell, E. J. Anaissie, A. Li, D. J. Sullivan

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations

Abstract

Candida species other than C. albicans have become a significant cause of infection in humans. Several of the more commonly isolated of these species are less susceptible to commonly used azole antifungal drugs, a factor that poses significant difficulties for effective treatment. The modern mycology laboratory has an important role to play in several aspects relating to these organisms, including therapy, detection, identification and epidemiological analysis. The application of molecular techniques and phylogenetic analysis has led to the identification of a new species of Candida associated with mucosal candidiasis in HIV-infected individuals named Candida dubliniensis, the clinical significance of which is currently under investigation. Molecular techniques are also being applied to the analysis of determinants involved in pathogenicity of species such as Candida glabratta. These approaches should lead to a better understanding of these organisms and there ability to cause disease and should also provide more effective treatment.

Original languageEnglish (US)
Pages (from-to)156-165
Number of pages10
JournalMedical Mycology, Supplement
Volume36
Issue number1
StatePublished - 1998

Keywords

  • Antifungal therapy
  • Molecular analysis
  • Non-C. albicans Candida
  • Opportunistic pathogens

ASJC Scopus subject areas

  • Microbiology
  • Immunology

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