Importance of animal models in understanding human carcinogenesis and its chemoprevention

T. J. Slaga, M. Hanausek, D. Morizot, Z. Walaszek

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Many animal models have significantly contributed to our understanding of the important events in the development of human cancer and its chemoprevention. Carcinogenesis is well known to be a multistep and multi- factorial phenomenon. Among the various organ systems that have been studied in any detail in the laboratory, the study of the induction of tumors in the skin of mice and the livers of rats and mice has produced the greatest understanding of the important biologic and cellular events involved in tumor initiation, promotion, and progression. During the past 30 years, these sequential events were also found to occur in bladder, breast, cheek pouch, esophagus, colon, stomach, lung, and prostate. These other animal models give strong support for the generality of the sequential nature of biologic events in carcinogenesis. Besides the skin and liver animal models, the fish model of cancer (Xiphophorus) has been useful as a genetic model of cancer.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalCancer Bulletin
Issue number6
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research


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