Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

Jianxin Lu, Lokendra Kumar Sharma, Yidong Bai

Research output: Contribution to journalArticlepeer-review

176 Scopus citations

Abstract

Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA (mtDNA) mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.

Original languageEnglish (US)
Pages (from-to)802-815
Number of pages14
JournalCell Research
Volume19
Issue number7
DOIs
StatePublished - Jul 2009

Keywords

  • Apoptosis
  • Cancer
  • Mitochondrial DNA mutation
  • ROS

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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